AB0147 OLDER AGE AT ONSET AND NOT DISEASE ACTIVITY IS ASSOCIATED WITH FUNCTIONAL DISABILITY AT RA DIAGNOSIS: RESULTS FROM AN EARLY ARTHRITIS COHORT

Background: Rheumatoid Arthritis (RA) is a chronic inflammatory arthropathy that potentially leads to loss of function and disability early in the disease course. (1) Optimizing physical one primary goals RA treatment (2). Several demographic, psychosocial clinical factors may influence impact upon capacity, understanding their relative contribution at diagnosis key an effective approach. Objectives: To evaluate functional time identify its demographic correlates cohort. Methods: We conducted cross-sectional study based on Rheumatology centre arthritis Consecutive patients with – less than 12 months duration– fulfilling ACR/EULAR 2010 and/or ACR 1987 classification criteria, were included. Variables collected from patients’ registries first rheumatology appointment after symptom’s onset. Functional was assessed using Health Assessment Questionnaire- Disability Index (HAQ-DI) (range 0 3, higher values indicating greater disability). Independent t -test, way-ANOVA Pearson’s correlation coefficient performed differences between groups. p<0.1 included stepwise multiple linear regression analysis assess independent association variables HAQ-DI baseline. Results: 71 (63.4% female, mean age 57.2 ±2.01 years). Mean score 1.42±0.08. Sociodemographic are described Table 1. There significant difference scores rheumatoid factor (RF) positive (mean 1.24±0.11) RF negative (1.61±0.113) patients. positively weakly correlated (r=0.48; p<0.001), CDAI (r=0.43; p=0.038), SDAI (r=0.49; p=0.015), moderately DAS28-3V (r=0.60; p<0.001) DAS28-3V-CRP p<0.001). The number tender (r=0.35; p=0.024) swollen joints (r=0.42; p= 0.005), ESR (r=0.46; p=0.001), CRP p=0.018), HADS-depression p=0.023) educational level (r= -0.48; p=0.002) also associated univariate analyses. After multivariate analysis, (β= 0.022 [95 CI 0.010 0.034]; 0.001) only predictor (R 2 = 0.46, p=0.001). Patients’ baseline sociodemographic characteristics. Age (years), (SD) 57.2±2.01 Educational 7.37±0.59 Employment: full-time, % 42.4 partial-time, 3.00 retired, 48.4 absenteeism last month, 1.50 Unemployed, 4.50 Disease duration presentation (weeks), 20.4±1.70 Morning stiffness >30 minutes, 83.0 positivity, 47.9 ACPA 53.5 Fibromyalgia, 6.60 DAS28-3V, 4.72±0.17 CDAI, 29.2±2.28 SDAI, 32.4±2.42 PtGA, 66.8±3.73 PhGA, 54.7±3.08 Pain intensity (VAS), 67.7±3.75 EQ-5D score, 0.26±0.039 HADS-depression, 7.17±0.87 Legend: ACPA- anti-citrullinated protein antibodies; ESR- erythrocyte sedimentation rate; CRP- c-reactive protein; DAS- activity score; CDAI- SDAI-simplified PtGA/ PhGA patient’s/physician’s global assessment general health; VAS- visual analogic scale; EQ-5D- EuroQoL 5-Dimensional Descriptive System; HADS-Hospital Anxiety Depression Scale. Conclusion: Older onset impairment diagnosis, by HAQ-DI, this cohort patients, irrespective other variables. This result suggests older newly diagnosed deserve special attention regarding function. References: [1]Wolfe F et al. Res Ther. 2010; 12(2): R35. [2]Smolen JS Ann Rheum Dis. 69:631-637. Disclosure Interests: None declared